Science Magazine ~ Vol 323 16th January 2009

New Sciet ntist magaz ine - 29th November 2008

RNA Technologies in Cardiovascular Medicine and Research

In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.t

Functional Proteomics

As the emerging field of proteomics continues to expand at an extremely rapid rate, the relative quantification of proteins, targeted by their function, becomes its greatest challenge. Complex analytical strategies have been designed that allow comparative analysis of large proteomes, as well as in depth detection of the core proteome or the interaction of a given protein of interest. In Functional Proteomics: Methods and Protocols, expert researchers describe the latest protocols being developed to address the problems encountered in high-throughput proteomics projects, with emphasis on the factors governing the technical choices for given applications. The case studies within the volume focus on the following three crucial aspects of the experimental design: 1) the strategy used for the selection, purification and preparation of the sample to be analyzed by mass spectrometry, 2) the type of mass spectrometer used and the type of data to be obtained from it, and 3) the method used for the interpretation of the mass spectrometry data and the used for the identification of the proteins in the different types of sequence data banks available. As a part of the highly successful Methods in Molecular Biology™ series, the chapters compile step-by-step, readily reproducible laboratory protocols, lists of the necessary materials and reagent

s, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Functional Proteomics: Methods and Protocols is an ideal resource for all scientists pursuing this developing field and its multitudinous data.

The Way of the Cell: Molecules, Organisms, and the Order of Life

What is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world's most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question.
What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms--in particular, the supremely well-researc

hed bacterium E. coli --because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements.

Proteomics for Biological Discovery

Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research.

• Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications
• Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future indu

  

  stry and basic science applications
• Discusses higher level integrative aspects, including technica l challenges and applications for drug discovery
• Accessible to the novice while providing experienced investigators essential information

Vitamins: Their Role in the Human Body

|Vitamins: Their Role in the Human Body is a single-source reference and textbook that assimilates the latest knowledge about vitamins' biological properties with regard to human nutrition. Introductory chapters cover historical and nutritional aspects of vitamins, detailed aspects of physiology and functional anatomy, biochemistry, immunology, the regulation of protein synthesis by nuclear hormone receptors, and much more. The subsequent thirteen chapters scrutinize each specific vitamin in turn. A glossary, bibliography, and index round out this expert resource intended especially for nutritionists, biochemists, physiologists, physicians, food scientists, food technologists, and other health professionals whether in the fields of research, teaching, or study

. An in-depth overview of vitamins, that does not shy from advanced scientific de

tail but is packed with tools to help the lay reader understand exactly what vitamins are and what they do. Highly recommended especially for health and science student and library collections..

Plant Hormone Signaling

| Plant growth is regulated by developmental programmes that can be modified by environmental cues acting through endogenous signaling molecules including plant hormones.This volume provides an overview of the biosynthesis, catabolism, perception and signal transduc tion of the individual hormone classes, followed by chapt ers on hormone distribution and transport, and the roles of hormone signaling in specific developmental processes. Particular attention is paid to the regulation of hormone signaling by environmental and developmental cues , sites of hormone m

etabolism and action, and interactions between h ormone signalin g pathways . The bo ok is directed at researchers and pro fessionals in plant biochemistry and molecular biology.

Principles of Cancer Genetics

Cancer genetics is a field of daunting breadth and depth. The literature describes hundreds of genes and genetic alterations that are variably associated with again as many disease states and risk factors. Integrating these disparate pieces of highly specialized information is challenging for the professional scientist and student alike. Prinicples of Cancer Genetics consolidates the main concepts of the cancer gene theory, and provides a framework for understanding the genetic basis of cancer. Focused on the most highly representative genes that underlie the most common cancers, Principles of Cancer Genetics is aimed at advanced undergraduates who have completed introductory courses in genetics, biology and biochemistry, medical students, and house medical house staff preparing for board examinations. Primary attention is devoted to the origins of cancer genes and the application of evolutionary theory to explain why the cell clones that harbor cancer genes tend to expand. The many points of controversy in cancer research are avoided, in favor of firmly established concepts. This book does not delve into tumor pathobiology beyond what is required to understand the role of genetic alterations in neoplastic growth. For students with a general interest in cancer, this book will provide a highly accessible overview. For students contemplating future study in the fields of oncology or cancer research, this book will be useful as a primer.
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An Introduction to Genetic Engineering

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Des Nicholl presents a new, fully revised, and expanded edition of his popular undergraduate-level textbook. The book retains many of the features of the original edition and still offers a concise technical introduction to the subject of genetic engineering. It is divided into three main sections: basic molecular biology, methods of gene manipulation, and modern applications of genetic engineering. Applications covered in the book include genomics, protein engineering, gene therapy, cloning, transgenic animals and plants, and bioethics. An Introduction to Genetic Engineering is essential reading for undergraduate students of biotechnology, genetics, molecular biology, and biochemistry..
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Introduction to Bioinformatics: A Theoretical and Practical Approach

A comprehensible introduction to the key biological, mathematical, statistical, and computer concepts and tools behind bioinformatics. For physical scientists, the book provides a sound biological framework for understanding the questions a life scientist would ask in the context of currently available computational tools. For life scientists, a complete discussion of the UNIX operating system offers biologists graphical-user-interface comfort in a command-line environment, plus an understanding of the installation and management of UNIX-based software tools. In the applications sections the book provides a common meeting ground for life and physical scientists. Here they will find examples of the management and analysis of DNA sequencing projects, the modeling of DNA as a statistical series of patterns, various methods of pattern discovery, protein visualization, and the use of multiple sequence alignment to infer both functional and structural biological relationships. An accompanying CD contains several full and limited trial-versions of the programs discussed in the text, as well as a complete set of illustrations from each chapter suitable for lectures and presentations..
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Biology at the Single Molecule Level

This is the first book solely devoted to single-molecule biochemistry and molecular biology. Authors were selected on the basis of their contribution to this new and exciting field, and were asked to focus more on the biological problems that can be approached using single-molecule techniques rather than on the techniques per se. It is thought that such techniques will eventually dominate the physical characterization of biologically important macromolecules.
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Analytical Biochemistry (3rd Edition)

Now an established handbook of principles and techniques, this text develops an understanding of the relevance of four fundamental properties of the analyte: shape, polarity, charge and size, to the three key types of analysis: separation, identification and quantification. The third edition of Analytical Biochemistry has now been fully updated in content and format, making it even more accessible to students learning how to select analytical techniques and recognise.
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Bioinformatics for Dummies

Explore the human genome and analyze DNA—without leaving your desktop! All it takes is the basics of molecular biology and the wealth of information in this friendly guide. You'll discover the online tools and useful tips you need to ask the right questions, analyze sequences, and compare results. It's a plain-English introduction to the field! .

The Science of Laboratory Diagnosis

This fully revised and updated edition of The Science of Laboratory Diagnosis provides a concise description of all common laboratory tests available in medical practice with notes on their application, the accuracy of each test, the historical background to the adoption of various tests and their effectiveness in diagnosis.medifast weight loss

* Well illustrated, with clear headings, tables, flow charts and pathology slides, most in full colour
* Provides an accessible reference book in which relevant information can be found easily
* Page design facilitates rapid assimilation of principles and key facts
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States of Mind: New Discoveries About How Our Brains Make Us Who We Are

An all-star lineup of scientists takes you to the front lines of brain research.

Are we born to be shy? Why do we remember some events so clearly and others not at all? Are creativity and depression somehow linked? Do our dreams really have deeper meanings?

Now in paperback, here medifast weight is a wonderfully accessible introduction to the most important recent findings about how our health,lawyers medifast behavior, accutane class actionfeelings, and identities are diet mesothelioma influenced by what goes on inside our brains. In this timely book, eight pioneering researchers offer lively and stimulating discussions on the most exciting discoveries as well as a new way of understanding our emotions, moods, memories, and dreams. Inside, .

Cells, Gels and the Engines of Life

Pollack's book is extremely insightful, although sometimes controversial. It looks at cell biology from a unique viewpoint. After reading this book, I have re-evaluated many established concepts in cell biology with new understanding and perspective. This is a must read for any serious student or researcher in the field of cell biology. I highly recommend this book. .

The Biochemistry of Cell Signalling

The Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained bydescribing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-ss in morphogenesis; cytokine signalling that controls haemopoiesis. .

Protein Engineering For Industrial Biotechnology

Protein engineering has proved to be one of the more fruitful technological approaches in biotechnology, being both very powerful and able to generate valuable intellectual property. This book aims to present examples in which the application of protein engineering has successfully solved problems arising in industrial biotechnology. There is a section on its use to enhance purification of recombinant proteins. The use of protein engineering to modify the activity or the stability of industrial enzymes from lipases to proteases, from carboxypeptidases to glucanases and glucosidases, and from pectin modifying enzymes to enzymes able to degrade recalcitrant compounds is extensively covered. It is shown how areas as diverse as agrofood technology, fine chemistry, detergents, bioremediation and biosensors receive significant contributions from protein and solvent engineering. The application of protein engineering to health care is also covered, from the development of new vaccines to new potential therapeutic proteins. A specific notation is given to protein engineering in the development of target molecules for drug discovery. International in scope, the many contributions are drawn from academia and industry. The text should be of interest to students and researchers in industrial biotechnology as well as to everybody interested in basic research in protein structure, molecular genetics, bio-organic chemistry, biochemistry, agrobiotechnology, pharmaceutical sciences and medicine .

Fundamental Virology 4th edition

Designed for graduate students and researchers in all biological and biomedical sciences, this volume brings together the basic science chapters from the two-volume Fourth Edition of Fields Virology. These 37 chapters comprise a comprehensive text and reference on the concepts and research
techniques of contemporary virology and the biochemistry, molecular biology, and replication of all viruses. The first part of the book covers basic concepts of general virology and the second part focuses on specific virus families.
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Guide to Publishing a Scientific Paper

Ann Körner has done a masterful job of presenting all of the important elements, in an order and style that makes sense and engages - and with a lightness and ease that demonstrates just what she describes!!!

Writing up your scientific results and getting them published can be two distinctly different processes. Körner meshes them seamlessly.

As a published scientist, who currently serves as a public information officer for science and medicine, and teaches science writing, I am delighted to have a book that I can recommend on every level to guide writers clearly in this process. .

Dictionary of DNA and Genome Technology

A one-of-a-kind dictionary giving clear, concise explanations of terms, techniques and tests used in DNA technology today.

* Covers topics relevant to medicine (diagnosis and gene therapy); veterinary science; biotechnology; biochemistry; pharmaceutical science/drug development; molecular biology; microbiology; epidemiology; genomics; environmental science; plant science/agriculture; taxonomy; and forensic science.

Biopharmaceuticals, an Industrial Perspective

Biopharmaceuticals, an Industrial Perspective provides a unique and up-to-date insight into the biopharmaceutical industry. Largely written by industrial authors, its scope is multidisciplinary.
The book is of particular relevance to scientists and allied professionals already employed in the biopharmaceutical industry, or to those seeking employment
within this industry. Its scope also renders it an ideal reference source for students undertaking advanced undergraduate or postgraduate courses in biotechnology, pharmaceutical science, biochemistry or medicine.

Biochemistry Demystified

Learn BIOCHEMISTRY without stressing out your brain CELLS

Trying to understand the chemical processes of living organisms but having trouble metabolizing the complex concepts? Here's your lifeline! Biochemistry Demystified helps synthesize your understanding of this important topic.


This fast and easy guide offers:

Simple enough for a beginner, but challenging enough for an advanced student, Biochemistry Demystified is your key to mastering this vital life sciences subject..

Introduction to Nutrition and Metabolism

The third edition of this leading textbook builds upon the excellent foundation of the previous two editions. It explains and explores the science underlying our current understanding of the interactions between diet and health, and the basis for current dietary goals and recommendations. It also provides a concise and authoritative description of the biochemistry that is essential to an understanding of the functions of nutrients and the importance of diet and nutrition for health and disease. The discussion of metabolic pathways and their regulation is illustrated by clear and simple diagrams, and is linked throughout to nutritional and physiological aspects..