Sunday, 19 April 2009

The Lehnninger Biochemsitry

The Lehnninger text has a long history, but given that biochemical knowledge doubles every 5 years or so, it matters what a text offers now, not in the past. The writing style is simple, direct, engaging, not too easy but neither too esoteric. The principles (as the title suggests) and the unity in diversity are emphasized, so that the student understands biochemical principles not merely facts, acronyms, pathways. The graphics are very professional. They are comparable to any review article in hot journals such as Nature, Science, Cell, etc. The rendering of protein surfaces, and the different angles through which a structure is seen is outstanding (a good example is the section on the ribosome). The structures have been rendered from the PDB (protein data bank) coordinates.


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Immunology

It's easy to read, easy to understand, very good graphics; Kuby is a very friendly book for new students, and for refreshing many concepts if you are very busy (and I bet you are!). I love it. But if you have more time available for reading, I would recommend Fundamental Immunology (Paul) and Cellular and Molecular Immunology by Abbas.
And try to keep up-to-date with new material on scientific magazines. See, in research you don't depend on books, that's only at the beginning or if you have to refresh some concepts. Once you have your knowledge, you will be reading papers on scientific magazines and less books. Many times, the concepts you have learned on books can change very fast. Science is a dynamic field, always changing.


Microbiology, 5th by Lannsing M. Preescott

Prescot, Harlley and Kleein's 5th edition provides a balanced, comprehensive introduction to all major areas of microbiology. Because of this balance, Microbiology, 5/e is appropriate for students preparing for careers in medicine, dentistry, nursing, and allied health, as well as research, teaching, and industry. Biology and chemistry are prerequisites. The Fifth Edition has been updated extensively to reflect the latest discoveries in the field.This book is nicely done, all together. The flow of information is well organized, with great cross-references and detailed graphs and pictures to help understand important concepts. Also, several appendices, a glossary, serve as helpful resources. The material is presented in a tasteful manner, not reducing the book to a mere picture book. This book, written for undergraduate and graduate students, gives serious information and is very detailed.
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Genes 8

Genes 8 changed the approach to begin with the sequence of the human and other genomes and starts with complete coverage of recent advances in genomics. The coverage of genomics is then integrated throughout the text.Two decades ago Benjamin Lewin’s Genes revolutionized the way we think about and teach molecular biology and molecular genetics. His approach unified the discipline by providing an integrated account of the structure and function of genes in both prokaryotes and eukaryotes.
Setting a standard for currency, Genes continually embraces emerging trends in this field, such as introducing the molecular aspect of the gene before the traditional analysis of formal genetics. Genes VIII continues to innovate; expanding the early discussion of the genome and integrating new information on gene sequencing throughout the text.


Friday, 6 March 2009

Developing Bioinformatics Computer Skills

Bioinformatics--the application of computational and analytical methods to biological problems--is a rapidly evolving scientific discipline. As a result of advances in gene sequencing, biological databases are growing exponentially. It's impossible for even the most zealous researcher to stay on top of necessary information in the field without the aid of computer-based tools. Written in a clear, engaging style, Developing Bioinformatics Computer Skills is for scientists and students who are learning computational approaches to biology, as well as for experienced biology researchers who are just starting to use computers to handle their data. The book covers the Unix file system, building tools and databases for bioinformatics, computational approaches to biological problems, an introduction to Perl for bioinformatics,data mining, data visualization, and tips for tailoring existing data analysis software to individual research needs. Developing Bioinformatics Computer Skills will help biologists develop a structured approach to biological data as well as the tools they'll need to analyze it.
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Modern Industrial Microbiology and Biotechnology


This book is directed towards undergraduates and beginning graduate students in microbiology, food science and chemical engineering. Those studying pharmacy, biochemistry and general biology will find it of interest. The section on waste disposal will be of interest to civil engineering and public health students and practitioners. For the benefit of those students who may be unfamiliar with the basic biological assumptions underlying industrial microbiology, such as students of chemical and civil engineering, elements of biology and microbiology are introduced. The new elements which have necessitated the shift in paradigm in industrial microbiology such as bioinformatics, genomics, proteomics, site-directed mutation, metabolic engineering, the human genome project and others are also introduced and their relevance to industrial microbiology and biotechnology indicated. As many references as space will permit are included. The various applicationsof industrial microbiology are covered broadly, and the chapters are grouped to reflect these applications. The emphasis throughout, however, is on the physiological, biochemical principles, and where possible, the genomic principles behind these applications.
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Biotechnology Unzipped: Promises And Realities


BIOTECHNOLOGY UNZIPPED is the most compelling evaluation of biotechnology I have read since Harsanyi & Hutton's GENETIC PROPHECY of almost 20 years ago. What makes this book so insightful is the "tradeoffs" perspective that Grace brings to the subject. In every instance where a particular technique is either in development or on the market, the possibilities for selective breeding, or genetic engineering, or composite materials, all hold both a promise and a peril. Grace, who has a Ph.D. in Zoology and considerable experience as a science writer, attempts to provide enough critical information in each case so that the reader will get a sense of what considerations are involved in any particular "biotechnology solution". What we learn about biotechnology from him is that every biotechnology decision has the following characteristics: * Costs and revenues (developments cost $millions, so the goal is profits) * Winners and losers (the rich could get lucky, the poor and vulnerable may not) * Benefits and detriments (solutions generate unintended & unwanted consequences) * Enthusiasts and detractors (arguments arise on all sides of biotechnology issues) The reason that the public is so ambivalent about biotechnology is that its supporters have been so inept at making their case. Biotechnology advocates seem to think that their's is just a problem of an "uninformed public" whom they can re- assure because they have "the facts". They obviously don't appreciate the most important principle of new-age , "They don't care how much you know until they know how much you care". What Grace shows is that the public does have cause to be concerned. There are no simple problems, no silver bullets, and no final solutions, even if biotechnology boosters pretend there are. If biotechnology advocates become willing to address these concerns, AND learn to manage the expectations of their stakeholders, then they can begin to earn the respect that will otherwise continue to elude them. Grace's book helps clarify all of this. . Grace's book helps clarify all of this.
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Wednesday, 4 March 2009

Molecular Biology of Protein Folding

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Author(s): P. Michael Conn

Series: Progress in Nucleic Acid Research and Molecular Biology, vol.83

Publisher: Academic Press

ISBN: 0123745942

Publication: 2008

Pages: 304

Description: The importance of protein folding has been recognized for many years. It is the underlying etiology in a large number of human diseases and it appears to be a novel method for cellular regulation of the expression of newly translated proteins. These volumes (Parts A & B) address this important topic. As a volume in Progress in Nucleic Acid Research and Molecular Biology, this book provides the latest information on the expanding research being conducted on protein folding. Illustrates how ubiquitin domain proteins are an ideal model system for experimental and computational studies of protein folding. Discusses structural wrapping and its importance in the contexts of network centrality, molecular disease, drug discovery and molecular theranostic engineering. Chapters written by international authors in engineering, biochemistry, physics, and computer science.

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Basic Endocrinology: An Interactive Approach

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Title: Basic Endocrinology: An Interactive Approach

Author(s): J. Matthew, M.D. Neal

Series: Advances in Pathology, Microscopy, and Molecular Morphology

Publisher: Blackwell Publishers

ISBN: 0632044292

Publication: 2000

Pages: 282

Description: Indiana Univ., Muncie. Introductory textbook for medical students and residents in a problem-based, self-assessment format. Presented as "frequently asked questions," and asks the student "why" rather than restating lecture material. One-third of the book consists of review questions accompanied by diagrams and photographs.

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Saturday, 14 February 2009

Proteins: Structure and Function

Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins.
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Transcription (Cell and Biomolecular Sciences)

transcription has moved forward at a furious pace over recent years, and an understanding of the processes involved in gene regulation and expression has become an essential element in biochemistry, genome biology, molecular biology and molecular genetics. In this timely book, the authors present an accessible, yet comprehensive, coverage suitable for students at a senior undergraduate level, and for postgraduates needing an overview of the current state of play. Transcription shows examples of transcription systems for eukaryotes and prokaryotes, indicates methods for studying transcription, and surveys the whole topic of transcription from many perspectives..

Wine Chemistry and Biochemistry

The aim of this book is to describe chemical and biochemical aspects of winemaking that are currently being researched. The authors have selected the very best experts for each of the areas. The first part of the book summarizes the most important aspects of winemaking technology and microbiology. The second most extensive part deals with the different groups of compounds, how these are modified during the various steps of the production process, and how they affect the wine quality, sensorial aspects, and physiological activity, etc. The third section describes undesirable alterations of wines, including those affecting quality and food safety. Finally, the treatment of data will be considered, an aspect which has not yet been tackled in any other book on enology. In this chapter, the authors not only explain the tools available for analytical data processing, but also indicate the most appropriate treatment to apply, depending on the information required, illustrating with examples throughout the chapter from enological literature.

Mitochondria, 2nd edition


This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria.

This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics..


Friday, 6 February 2009

Drug-Drug Interactions in Pharmaceutical Development

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Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.

Gene cloning

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Description: Cloning genes has become such a routine part of molecular biology, and the approaches to it so many and diverse, undergraduates can easily be overwhelmed. Gene Cloning is designed to give the undergraduate a broad overview of the subject, guiding the student through the basic elements involved and their utility, and further through the interpretation of results and datasets. Having understood the basic processes, the reader is introduced to some of the most common uses of gene cloning, from applications with more research-oriented goals to practical applications in biotechnology in medicine. Clearly presented in two-colour text, Gene Cloning is essential reading for undergraduates in the molecular life sciences.

Gene Regulation

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Description: Gene regulation is an essential process in the development and maintenance of a healthy body, and as such is a central focus in both basic science and medical research. Gene Regulation, Fifth Edition, provides the student with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview. For this fifth edition, in addition to extensive updating of existing material, sections on large-scale methodologies have been expanded, and a new section included on regulation by small interfering RNAs. More detail has been added on the role of multi-protein complexes in transcriptional activation and the discussion of the regulation of factor activity by specific modifications to include acetylation and ubiquitination as well as phosphorylation. The final chapter on gene regulation and human disease now includes additional novel examples, such as RNA edition in motor neurone disease, role of the transcriptional co-activator CBP in Alzheimer's disease and PML-RAR involvement in acute promyelocytic leukemia.

Boost Your Interview IQ


How to become an interview genius and land the job of your dreams

If a job interview is an oral exam in which give the right answers to a set of questions in order to get hired, then this is the ultimate guide to acing the exam. Written by The Interview Coach at Monster.com, Boost Your Interview IQ offers an enjoyable, interactive way to prepare for and succeed at any job interview.

Combining the features of a step-by-step guide and a skill-building workbook, it:

* Shows job seekers how to craft job-winning answers to the 50 key questions interviewers ask
* Features an Interview IQ Test, interview skill-building exercises, and other interview aptitude boosting tools
* Teaches candidates how to shape their experiences into stories that showcase their skills, knowledge, and personalities
* Offers proven techniques for acing the behavioral interview--the popular new wave interviewing strategy How to become an interview genius and land the job of your dreams

Tuesday, 3 February 2009

Nature Reviews Molecular Cell Biology [Volume 8 Jan (2007) - Sep (2007)]

Molecular cell biology is a marriage
of two distinct, yet complementary, disciplines. In its traditional sense, the term 'molecular biology' refers to study of the macromolecules essential to life — nucleic acids and proteins. The field of cell biology is a natural extension of this, integrating what we know at the molecular level into an understanding of processes and interactions at the cellular level. Only by combining both fields can we paint a broad picture of essential biological processes such as how cells divide, grow, communicate and die.

Nature Reviews Molecular Cell Biology takes readers on a journey from the nucleus of a cell to its boundaries and beyond. It features Reviews and Perspectives articles on a broad range of topics, and highlights important primary papers and technological progress

Soil Microbiology, Ecology and Biochemistry

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Now in its third edition, this classic textbook includes basic concepts and applications in agriculture, forestry, environmental science, and a new section entirely devoted to ecology. This revised and updated edition guides students through biochemical and microbial processes in soils and introduces them to microbial processes in water and sediments. Soil Microbiology, Ecology, and Biochemistry serves as an invaluable resource
for students in biogeochemistry, soil microbiology, soil ecology, sustainable agriculture, and environmental amelioration.

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Animal Biotechnology: Science-Based Concerns


Genetic-based animal biotechnology has produced new food and pharmaceutical products and promises many more advances to benefit humankind. These exciting prospects are accompanied by considerable unease, however, about matters such as safety and ethics. This book identifies science-based and policy-related concerns about animal biotechnology�key issues that must be resolved before the new breakthroughs can reach their potential. The book includes a short history of the field and provides understandable definitions of terms like cloning. Looking at technologies on the near horizon, the authors discuss what we know and what we fear about their effects�the inadvertent release of dangerous microorganisms, the safety of products derived from biotechnology, the impact of genetically engineered animals on their environment. In addition to these concerns, the book explores animal welfare concerns, and our societal and institutional capacity to manage and regulate the technology and its products. This accessible volume will be important to everyone interested in the implications of the use of animal biotechnology.t

Wednesday, 21 January 2009

Science Magazine ~ Vol 323 16th January 2009









New Sciet ntist magaz ine - 29th November 2008

RNA Technologies in Cardiovascular Medicine and Research

ImageIn this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.t

Functional Proteomics

Image As the emerging field of proteomics continues to expand at an extremely rapid rate, the relative quantification of proteins, targeted by their function, becomes its greatest challenge. Complex analytical strategies have been designed that allow comparative analysis of large proteomes, as well as in depth detection of the core proteome or the interaction of a given protein of interest. In Functional Proteomics: Methods and Protocols, expert researchers describe the latest protocols being developed to address the problems encountered in high-throughput proteomics projects, with emphasis on the factors governing the technical choices for given applications. The case studies within the volume focus on the following three crucial aspects of the experimental design: 1) the strategy used for the selection, purification and preparation of the sample to be analyzed by mass spectrometry, 2) the type of mass spectrometer used and the type of data to be obtained from it, and 3) the method used for the interpretation of the mass spectrometry data and the used for the identification of the proteins in the different types of sequence data banks available. As a part of the highly successful Methods in Molecular Biology™ series, the chapters compile step-by-step, readily reproducible laboratory protocols, lists of the necessary materials and reagent

s, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Functional Proteomics: Methods and Protocols is an ideal resource for all scientists pursuing this developing field and its multitudinous data.

Sunday, 18 January 2009

The Way of the Cell: Molecules, Organisms, and the Order of Life

What is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world's most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question.
What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms--in particular, the supremely well-researc

hed bacterium E. coli --because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements.

Proteomics for Biological Discovery

Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research.
  • Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications
  • Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future indu

    stry and basic science applications
  • Discusses higher level integrative aspects, including technica l challenges and applications for drug discovery
  • Accessible to the novice while providing experienced investigators essential information


Vitamins: Their Role in the Human Body

|Vitamins: Their Role in the Human Body is a single-source reference and textbook that assimilates the latest knowledge about vitamins' biological properties with regard to human nutrition. Introductory chapters cover historical and nutritional aspects of vitamins, detailed aspects of physiology and functional anatomy, biochemistry, immunology, the regulation of protein synthesis by nuclear hormone receptors, and much more. The subsequent thirteen chapters scrutinize each specific vitamin in turn. A glossary, bibliography, and index round out this expert resource intended especially for nutritionists, biochemists, physiologists, physicians, food scientists, food technologists, and other health professionals whether in the fields of research, teaching, or study

. An in-depth overview of vitamins, that does not shy from advanced scientific de

tail but is packed with tools to help the lay reader understand exactly what vitamins are and what they do. Highly recommended especially for health and science student and library collections..

Plant Hormone Signaling

| Plant growth is regulated by developmental programmes that can be modified by environmental cues acting through endogenous signaling molecules including plant hormones.This volume provides an overview of the biosynthesis, catabolism, perception and signal transduc tion of the individual hormone classes, followed by chapt ers on hormone distribution and transport, and the roles of hormone signaling in specific developmental processes. Particular attention is paid to the regulation of hormone signaling by environmental and developmental cues , sites of hormone m

etabolism and action, and interactions between h ormone signalin g pathways . The bo ok is directed at researchers and pro fessionals in plant biochemistry and molecular biology.

Friday, 16 January 2009

Principles of Cancer Genetics

Cancer genetics is a field of daunting breadth and depth. The literature describes hundreds of genes and genetic alterations that are variably associated with again as many disease states and risk factors. Integrating these disparate pieces of highly specialized information is challenging for the professional scientist and student alike. Prinicples of Cancer Genetics consolidates the main concepts of the cancer gene theory, and provides a framework for understanding the genetic basis of cancer. Focused on the most highly representative genes that underlie the most common cancers, Principles of Cancer Genetics is aimed at advanced undergraduates who have completed introductory courses in genetics, biology and biochemistry, medical students, and house medical house staff preparing for board examinations. Primary attention is devoted to the origins of cancer genes and the application of evolutionary theory to explain why the cell clones that harbor cancer genes tend to expand. The many points of controversy in cancer research are avoided, in favor of firmly established concepts. This book does not delve into tumor pathobiology beyond what is required to understand the role of genetic alterations in neoplastic growth. For students with a general interest in cancer, this book will provide a highly accessible overview. For students contemplating future study in the fields of oncology or cancer research, this book will be useful as a primer.
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