Biostatistics and Microbiology

This “nuts and bolts” book provides a condensation of biostatistical methods that applied microbiology researchers need to perform data analyses. Based on the author’s more than two decades of applied research and teaching experience, it is presented in a straight-forward manner, applicable by practicing microbiologists with minimal backgrounds in mathematics. All methods rely only on the use of a basic hand-held calculator. The overriding goal of this book is to ground one’s microbiological expertise and experience in one’s research pursuits, using biostatistics not as a black box, but as a tool. The book begins with a broad discussion of the experimental process, leading to one-sample, two-sample, and multi-sample comparisons. Each regression analysis will be presented, as well as an example. Nonparametric methods will be discussed, as well as when they should be applied. Finally, special topics of statistics in microbiology (i.e., viral, plant, animal, human, food, industrial and microbial microbiology) will be presented.

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Innovations in Chemical Biology

The growing role of chemistry, combined with the contribution of chemical and pharmaceutical industries to the science of mankind, are continuously advancing. The system for training researchers in the various areas of chemistry has maintained a largely traditional and single disciplinary focus, although many investigators have broadened their selection of research techniques to encompass organized and integrated programs. As a multidisciplinary, Chemical Biology is one of the fastest expanding areas of science during this century. The interdisciplinary study of molecules in living systems at a health science campus aids the integration of the traditional disciplines of chemistry and biology. This is achieved through understanding the molecular mechanisms of biological processes, which provides the opportunity to manipulate them in a defined and predictable way. Looking forward to the next century, we will witness many more remarkable achievements within Chemistry with its application to different fields, resulting in countless benefits to human health and standards of living.

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The Physical Foundation of Protein Architecture

A protein requires its own three-dimensional structure for its biological activity. If a chemical agent is added, the biological activity is lost, and the three-dimensional structure is destroyed to become a random coil state. But when the chemical agent is removed, the biological activity is recovered, implying that the random coil state turns back into the original complex structure spontaneously. This is an astonishing event. "The Physical Foundation of Protein Architecture" is intended to solve this mystery from the physicochemical basis by elucidating the mechanism of various processes in protein folding. The main features of protein folding are shown to be described by the island model with long range hydrophobic interaction which is capable of finding the specific residue, and the lampshade criterion for disulfide bonding. Various proteins with known structure are refolded, with the purpose of uncovering the mechanism of protein folding. In addition, ab initio method for predicting protein structure from its amino acid sequence is proposed.

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HIV Protocols: Second Edition

Major advances in HIV treatment, many areas require more study, in order to create efficacious, potent antiretrovirals that can suppress viral load completely and durably without toxic side effects, to define unknown drug targets and fine-tune known targets, and to better understand the interplay between viral and host factors. In "HIV Protocols, Second Edition", expert researchers provide clear, state-of-the-art methods for the study of HIV. Directed toward three specific goals, this text aims to document up-to-date protocols for select aspects of HIV biology, to bring together both virological and immunological approaches in a single, convenient volume, and to present a comprehensive account of a range of techniques not available in any existing HIV protocol book. As a volume in the highly successful Methods in Molecular Biology™ series, the chapters include brief introductions to the subject, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections containing priceless tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, "HIV Protocols, Second Edition" is an ideal guide to the wide array of techniques used in fundamental or applied research into the biology and pathogenesis of HIV-1.

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Science

Cover
A mosaic of visible to near-infrared images of the surface of Mercury, obtained by the MESSENGER spacecraft on 14 January 2008. The circular feature in the upper right is the Caloris impact basin, 1500 kilometers in diameter.

Scientific Writing: Easy When You Know How

This comprehensive and practical book covers the basics of grammar as well as the broad brush issues such as writing a grant application and selling to your potential audience. The clear explanations are expanded and lightened with helpful examples and telling quotes from the giants of good writing. These experienced writers and teachers make scientific writing enjoyable.
Description: This is a very well written book on scientific writing that is easy to read and follow. The format of boxed tables presents the information concisely.
Purpose: The purpose is to make scientists better writers. Writing well is a crucial component of scientific success, one that is often overlooked by formal scientific training. With scientific data generated worldwide, having a book that summarizes the standards of writing in English is very helpful. The authors have done an excellent job in meeting their objectives.

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The Application of Biotechnology to Industrial Sustainability

In more and more industrial sectors, companies are becoming aware of the importance of sustainable development and of the great potential of biotechnology. Biotechnology can help improve the environmental friendliness of industrial activities and lower both capital expenditure and operating costs. It can also help reduce raw material and energy inputs and waste. This volume brings together for the first time a broad collection of case studies on biotechnology applications in industrial processes and subjected them to detailed analysis in order to tease out essential lessons for industrial managers and for government policy makers. It will encourage the former and provide the latter with basic materials for programme development

Viruses vs. Superbugs

This book tells the fascinating story of the discoverers of phages in the west and the Soviet Union. Thomas Häusler follows the trail of one pioneer killed by Stalin's secret service, and his successors in today's war-torn Georgia, accompanying patients taking phages because standard drugs fail them and investigates how these long-forgotten cures may help sick people today.

Pharmacokinetics and Metabolism in Drug Design

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs.While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Stem Cell Research and Cloning

The debates presented in Point/Counterpoint are among the most interesting and controversial in contemporary American society,but studying them is more than an academic activity.They affect every citizen; they are the issues that today’s leaders debate and tomorrow’s will decide. The reader may one day play a central role in resolving them. Why study both sides of the debate? It’s possible that the reader will not yet have formed any opinion at all on the subject of this volume but this is unlikely. It is more likely that the reader will already hold an opinion, probably a strong one,and very probably one formed without full exposure to the arguments of the other side. It is rare to hear an argument presented in a balanced way, and it is easy to form an opinion on too little information; these books will help to fill in the informational gaps that can never be avoided. More important, though, is the practical function of the series: Skillful argumentation requires a thorough knowledge of bothsides though there are seldom only two, and only by knowing what an opponent is likely to assert can one form an articulate response.

Cell Fusion: Overviews and Methods

Exciting work in the past decade has revealed commonalities and differences among individual cell fusion events. In Cell Fusion: Overviews and Methods, a team of leading experts provide a collection of overviews that outline our current understanding of cell fusion and methods that present classic and state-of-the-art experimental approaches in a variety of systems. Divided into two convenient parts, the volume begins with nine overviews which describe different cell fusion events in models from yeast to mammals, and it continues with thirteen chapters illustrating commonly used methods to assay cell fusion in particular systems. As a part of the highly successful Methods in Molecular Biology™ series, these methods chapters compile step-by-step, readily reproducible protocols with lists of the necessary materials and reagents, along with tips on troubleshooting and avoiding known pitfalls. Cutting-edge and user-friendly, Cell Fusion: Overviews and Methods serves as a comprehensive resource for anyone, expert or novice, interested in the fascinating biological process of cell fusion.

DNA Methylation: Methods and Protocols

Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace. Due to this fact, DNA Methylation: Methods and Protocols, Second Edition completely revises, updates, and expands upon the popular first edition with the most current novel techniques, easier to use and more refined by the tested experience of leading experts. This revision reflects contemporary study of the subject: the analysis of gene-specific DNA methylation patterns has been complemented by genome-wide approaches, and epigenomics takes a central place. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume present brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, DNA Methylation: Methods and Protocols, Second Edition is the perfect resource for scientists who wish to further our understanding of the molecular processes that determine the genomic DNA methylation landscape and for those who aim to identify and implement DNA methylation-based biomarkers for clinical and diagnostic applications.

Mass Spectrometry: A Textbook

This book is tailored for students and professionals as well as novices from other fields to mass spectrometry. It will guide them from the basics to the successful application of mass spectrometry in their daily research. Starting from the very principles of gas-phase ion chemistry and isotopic properties, it leads through the design of mass analyzers and ionization methods in use to mass spectral interpretation and coupling techniques. Step by step the readers will learn how mass spectrometry works and what it can do as a powerful tool in their hands. The book comprises a balanced mixture of practice-oriented information and theoretical background. The clear layout, a wealth of high-quality figures and a database of exercises and solutions, accessible via the publisher’s web site, support teaching and learning.

Molecular Biomethods Handbook

Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. Molecular Biomethods Handbook, 2nd Edition expands upon the techniques included in the first edition, providing theory, outlines of practical procedures, and applications for a range of techniques. Part A of the book describes nucleic acid methods, such as gene expression profiling, microarray analysis and quantitative PCR. In Part B, protein and cell-based methods are outlined, in subjects ranging from protein engineering to high throughput screening. Written by a well-established panel of research scientists, Molecular Biomethods Handbook, 2nd Edition provides an up to date collection of methods used regularly in the authors’ own research programs. This book will prove to be an invaluable reference for those engaged in or entering the field of molecular biology, and will provide the necessary background for those interested in setting up and using the latest molecular techniques.

Meat Biotechnology

Meat and meat products constitute one of the most important foods in western societies. However, the area of meat biotechnology is not as comprehensively covered as other areas of food biotechnology. Missing from this area are the recent developments for better sensory and nutritional quality as well as improved safety. The main goal of this book is to provide the reader with the recent developments in biotechnology and their applications in the meat processing chain. To achieve this goal, the book is divided into four parts. The first part deals with the use of modern biotechnology applied to farm animals. The second part focuses on the recent biotechnological developments in starter cultures for better meat fermentation. The third part discusses current approaches to improve the quality and nutritional properties of meats. The final part presents the latest advances in protection against foodborne pathogens, and other recent trends in the field. Written by distinguished international contributors, this book brings together the advances in such varied and different biotechnological topics.

Nature Cell Biology Sep Volume 10

What Can You Do with a Major in Biology?

The complete guide to making the most of a biology degree

One of the top ten college majors in America today, biology can lead to a spectrum of careers?from jobs in the ever-expanding health care industry to options in oceanography, food chemistry, and botany. Students considering a biology major and grads of any age seeking new directions will find What Can You Do with a Major in Biology? the most thorough, easy-to-use resource available?with real profiles, outlines of career paths, salary levels, and much more.

Series author Jennifer A. Horowitz (New York, NY) holds degrees from Columbia University?s Teachers College and from Barnard College in writing. She has worked in New York City schools, with educational publishers, and as an advisor to parents of gifted children.

Gene and Cell Therapy

The latest edition of Gene and Cell Therapy provides comprehensive coverage of all aspects of the tools and state-of-the-art technologies that are currently available in this field. Written by international leaders, this third edition features 12 additional chapters that address such new topics as gene and cell therapies for diabetes and cardiovascular disease, relevant nanotechnologies, siRNA therapeutics, dendrimers, clinical trials, human embryonic stem cell research, tissue engineering, and novel polymers. All chapters in the text have been substantially updated and revised to reflect the latest information available in the field.